منابع مشابه
Lymphocytotoxic antibodies in systemic lupus
The lymphocytotoxicity of 33 lupus sera was tested against purified helper/inducer (OKT4) and cytotoxic/suppressor (OKT8) subsets of T lymphocytes at 15°C and 37°C in vitro. There was significantly less killing of both OKT4 and OKT8 cells at 37°C (p<0001 and p<0-01) and the ratio of OKT4/OKT8 cell killing at 15°C (1-39 (0.73); mean (SD)) was different from that observed at 37°C (0.79 (0.42)) (p...
متن کاملIncidence and Correlation with Lymphocytotoxic Antibodies
The anti-RNA antibodies were present in consanguineous household contacts but not in nonconsanguineous household contacts. These findings strengthen the hypothesis that both an environmental agent, possibly a virus, as well as the genetic response are important in the pathogenesis of SLE. Family members may therefore be a logical population in whom to search for specific antibodies to a viral a...
متن کاملLymphocytotoxic antibodies in systemic lupus erythematosus: their clinical significance.
Cold-reactive lymphocytotoxic antibodies are present in the serum of most patients with systemic lupus erythematosus (SLE) (Mittal et al., 1970; Terasaki et al., 1970). They appear to be equally cytotoxic for autologous and heterologous lymphocytes (Stastny and Ziff, 1971). Studies of the nature of these antibodies showed that their cytotoxic effect is temperature-dependent and maximal at 15°C,...
متن کاملHumoral rejection associated with antidonor lymphocytotoxic antibodies following liver transplantation.
H EPATIC allografts are more resistant than other solid organs to antibody-mediated rejection, and human hepatic transplants can be successfully performed in the face of donor-specific lymphocytotoxic antibodies (positive crossmatch).1.2 However, we recently reported a significant decrease in patient and graft survival when a liver transplant was performed against a positive IgG lymphocytotoxic...
متن کاملSerum lymphocytotoxic antibodies and neurocognitive function in systemic lupus erythematosus.
The hypothesis that lymphocytotoxic antibodies are associated with neuropsychiatric involvement in systemic lupus erythematosus (NP-SLE) is re-evaluated in this study. In an unselected cohort of 98 women with SLE a cross-sectional study has been performed to analyse associations among standardised clinical, neurological, and neuropsychological assessments and lymphocytotoxic antibodies measured...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1977
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780200405